ICSI
Fertilization happens naturally when one sperm from the ejaculate pierces the egg, which is referred to as an oocyte in science and is released throughout the menstrual cycle. To merge with the female gamete, the sperm must penetrate the zona pellucida, or oocyte’s shell.
In certain instances, low gamete quality or interaction issues can cause a considerable decrease in gamete production, or physiological deficiencies can cause the process of fertilization to be hindered or even stopped.
Two fundamental methods exist to address these deficiencies in Assisted Reproduction Techniques (ART):
- The current state of in vitro fertilization (IVF)
- Cytoplasmic injection of sperm (ICSI).
ICSI - The procedure
To get beyond the limitations of conventional IVF, like insufficient gamete interaction and insufficient semen samples, ICSI uses a single sperm injected into the egg. As a result, ICSI has become the most used IVF method. Using an advanced micromanipulation station (which comprises a microscope, microinjectors, and micropipettes), each sperm must be individually selected and rendered immobile. During the microinjection, the egg must be held in place as the sperm is inserted and released inside its inner area. Every oocyte will be checked for indications of a healthy fertilization process the day following the microinjection.
Conventional IVF
The procedure was followed. The contact between the oocytes and sperm is the cornerstone of traditional in vitro fertilization. Each oocyte and the surrounding granulose cells are placed in a drop of culture fluid containing a concentration-controlled sperm suspension after the egg is retrieved. The single sperm should eventually reach the egg and fertilize it as a result of this contact.
Limitations of the technique
The procedure was followed. Conventional IVF is based on the interaction between the sperm and the oocytes that produce eggs. Each oocyte and the surrounding granulose cells are placed in a drop of culture fluid containing a concentration-controlled sperm suspension after the egg is retrieved. The single sperm should eventually reach the egg and fertilize it as a result of this contact.
Who is this for?
Tubal factors, uterine factors, premature ovarian failure, ovulatory dysfunction, endometriosis, decreased ovarian reserve, and unexplained infertility are all indications for traditional IVF and ICSI. ICSI is especially advised for samples with abnormal semen analysis (most commonly low concentration or motility), instances where there are a restricted number of oocytes accessible, or previous fertilization failures with traditional IVF. As a result, conventional IVF is usually recommended in patients with a good prognosis when the quality of both gametes is not an issue.
Ovarian Stimulation
Sperm Preparation
Egg Retrieval
Egg and Sperm Examination
Introduction of sperm into The Egg
Transferring fertilized eggs into the uterus
ICSI (Intra Cytoplasmic Sperm Injection) is an advanced form of IVF where a single healthy sperm is directly injected into an egg in the laboratory to achieve fertilization. It is highly effective for couples with male infertility issues.
In IVF, thousands of sperm are placed with an egg to allow natural fertilization, while in ICSI, a single sperm is injected directly into the egg. This increases the chances of fertilization when sperm quality is poor.
ICSI has a high success rate, especially in cases of male infertility. At Mother Divine Fertility, with advanced technology and expert embryologists, we achieve strong fertilization and pregnancy outcomes.
Yes, ICSI is safe. It has been widely used for decades. Risks are minimal but, like IVF, may include multiple pregnancy or rare genetic concerns. Our specialists ensure safe and ethical practices.
An ICSI cycle takes about 4–6 weeks, similar to IVF. It includes ovarian stimulation, egg retrieval, sperm selection, ICSI fertilization, embryo culture, and embryo transfer.
The cost depends on individual treatment needs, medications, and whether additional procedures (like embryo freezing or donor programs) are required. We offer affordable and transparent ICSI packages tailored to couples’ needs.
